Sensitive thyrotrophin assays: excellent when properly used.
نویسندگان
چکیده
منابع مشابه
The Role of Thyrotrophin Receptor Antibody Assays in Graves' Disease
Thyrotrophin receptor antibodies (TRAb) exist as stimulating or blocking antibodies in the serum (neutral TRAb have been identified recently). The clinical features of GD occur when stimulating TRAb predominate. But the relationship of TRAb to clinical phenotype and outcome is not clear when current assay methods are used. Therefore no consensus exists about its utility in diagnosing and predic...
متن کاملClinical hyperthyroidism due to non-neoplastic inappropriate thyrotrophin secretion.
We report a case of hyperthyroidism due to inappropriate thyrotrophin (TSH) secretion in a patient with selective pituitary resistance to thyroid hormone action. Symptoms of hyperthyroidism in patients with this disorder are usually mild, implying some peripheral tissue resistance to the metabolic effects of thyroid hormone. Our patient had unusually severe symptoms, including marked weight los...
متن کاملAnalytical and diagnostic accuracy of "second generation" assays for thyrotrophin receptor antibodies with radioactive and chemiluminescent tracers.
AIMS To investigate the analytical and diagnostic accuracy of thyrotrophin (TSH) receptor antibody assays using recombinant human TSH receptors. METHODS Sera from 68 patients with Graves' disease, 23 patients with autoimmune thyroiditis, and 119 healthy controls were evaluated in four different laboratories using both radioactive and chemiluminescent tracers. Functional sensitivity, interlabo...
متن کاملEnhancing effect of corticotrophin on thyrotrophin produced exophthalmos in fish.
Goldfish (Carassius auratus, var. japonicus, subvar. bicaudatus) respond to the administration of thyrotrophic hormone with exophthalmos. Eye protrusion increases with simultaneous injections of corticotrophin. Retrobulbar injections of normal saline, human serum or pituitary hormones produce a transient exophthalmos, which is much more persistent when thyrotrophin is injected. Previous treatme...
متن کاملNormal thyrotrophin response to intravenous thyrotrophin releasing hormone administration: the best index of optimal L-thyroxine therapy in primary hypothyroidism.
Normalization of basal thyrotrophin (TSH) level is used as the endpoint in L-thyroxine (L-T4) therapy of primary hypothyroidism. However, several reports have questioned the reliability of this index because of seasonal variation of TSH. Therefore, we studied 85 consecutive patients with primary hypothyroidism over a period of 3.5 y. In these patients, TSH response (delta TSH) to intravenous th...
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ورودعنوان ژورنال:
- British medical journal
دوره 295 6612 شماره
صفحات -
تاریخ انتشار 1987